Symptoms
NF-1 is more common and is characterized by multiple (more than 5) tan patches on the skin (café-au-lait spots), freckles in the groin or armpit, nodules within the iris of the eyes, skin neurofibromas (small, rubbery skin lesions), bone defects, and visual disorders.
Children with NF-1 are susceptible to neurologic complications including masses in the brain and spinal cord.
NF-2 accounts for only 10 percent of all cases and is characterized by bilateral acoustic neuromas (masses around the eight cranial nerve in the brain) which causes hearing loss, facial weakness, headache, or unsteadiness. Café-au-lait spots and skin neurofibromas are much less common. Brain tumors and lens abnormalities (in the eye) may also occur.
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